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Fluoxetine works by preventing the reuptake of one neurotransmitter, serotonin, by nerve cells after it has been released. Some patients may experience withdrawal reactions upon stopping fluoxetine. The dose of fluoxetine should be gradually reduced when therapy is discontinued. Be sure your doctor knows about all other medicines you use. Skip the missed dose if it is almost time for your next scheduled dose. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed. Call your doctor for medical advice about side effects.
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You should consult with a medical professional if you have any questions about your health. Years of development and testing finally led to approval of fluoxetine for marketing. Three randomized, double-blind, placebo-controlled studies showed a decrease in the frequency and severity of migraine headaches with fluoxetine therapy. Because uptake inactivates serotonin by removing it from the synaptic cleft, uptake inhibition by fluoxetine enhances serotonergic function. Fluoxetine does not interact directly with postsynaptic serotonin receptors, muscarinic-cholinergic receptors, histaminergic receptors, or alpha-adrenergic receptors.
The liver then metabolizes fluoxetine into norfluoxetine, a desmethyl metabolite, which is also a serotonin reuptake inhibitor. Fluoxetine versus other types of pharmacotherapy for depression. Possible involvement of cholinergic and opioid receptor mechanisms in fluoxetine mediated antinociception response in streptozotocin-induced diabetic mice. Plasma catecholamine levels after fluoxetine treatment in depressive patients. Fluoxetine for migraine prophylaxis: a double-blind trial. Fluoxetine prophylaxis of migraine.
A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. The fetal safety of fluoxetine: a systematic review and meta-analysis. Fluoxetine attenuates alcohol intake and desire to drink. Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents. Double-blind trial of fluoxetine: chronic daily headache and migraine. Fluoxetine and premature ejaculation: a double-blind, crossover, placebo-controlled study. Double-blind placebo-controlled trial of fluoxetine in smoking cessation treatment including nicotine patch and cognitive-behavioral group therapy.
The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. Fluoxetine and fluvoxamine for treatment of chronic pain. Fluoxetine for the treatment of childhood anxiety disorders. The effects of fluoxetine in the overdose patient. Benign course in a child with a massive fluoxetine overdose. Timing of onset of antidepressant response with fluoxetine treatment.
Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort. Use of fluoxetine in anorexia nervosa before and after weight restoration. These studies indicate that fluoxetine may help to treat depression and obsessive-compulsive disorder in children. Blackwell’s five-minute veterinary consult clinical companion. Fluoxetine works by affecting a part of your brain that controls your mood. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Visit your doctor or health care professional for regular checks on your progress. Fluoxetine is used to treat depression, obsessive-compulsive disorders, panic disorder, and bulimia (binge eating and purging). Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression or mood disturbances, eating disorders, or obsessive or compulsive symptoms. While you are taking fluoxetine you may need to be monitored for worsening symptoms of depression and suicidal thoughts at the start of therapy or when doses are changed. This medication will cause you to become drowsy.
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