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The information provided includes the cost of the drug and the type of drug – tablet, capsule, syrup, cream, gel, ointment, liquid or injection. Prices can change depending on many factors, including local taxes. This makes fluoxetine highly effective in treatment of clinical depression cases where symptoms like depressed mood and lack of energy exist. Fluoxetine affects neurotransmitters, the chemicals that nerves within the brain use to communicate with each other. Fluoxetine works by preventing the reuptake of one neurotransmitter, serotonin, by nerve cells after it has been released. Some patients may experience withdrawal reactions upon stopping fluoxetine. The dose of fluoxetine should be gradually reduced when therapy is discontinued.
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Years of development and testing finally led to approval of fluoxetine for marketing. Three randomized, double-blind, placebo-controlled studies showed a decrease in the frequency and severity of migraine headaches with fluoxetine therapy. Because uptake inactivates serotonin by removing it from the synaptic cleft, uptake inhibition by fluoxetine enhances serotonergic function. Fluoxetine does not interact directly with postsynaptic serotonin receptors, muscarinic-cholinergic receptors, histaminergic receptors, or alpha-adrenergic receptors. The liver then metabolizes fluoxetine into norfluoxetine, a desmethyl metabolite, which is also a serotonin reuptake inhibitor.
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Fluoxetine versus other types of pharmacotherapy for depression. Possible involvement of cholinergic and opioid receptor mechanisms in fluoxetine mediated antinociception response in streptozotocin-induced diabetic mice. Plasma catecholamine levels after fluoxetine treatment in depressive patients. Fluoxetine for migraine prophylaxis: a double-blind trial. Fluoxetine prophylaxis of migraine.
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A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. The fetal safety of fluoxetine: a systematic review and meta-analysis. Fluoxetine attenuates alcohol intake and desire to drink. Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents. Double-blind trial of fluoxetine: chronic daily headache and migraine.
Fluoxetine and premature ejaculation: a double-blind, crossover, placebo-controlled study. Double-blind placebo-controlled trial of fluoxetine in smoking cessation treatment including nicotine patch and cognitive-behavioral group therapy. The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. Fluoxetine and fluvoxamine for treatment of chronic pain. Fluoxetine for the treatment of childhood anxiety disorders.
The effects of fluoxetine in the overdose patient. Benign course in a child with a massive fluoxetine overdose. Timing of onset of antidepressant response with fluoxetine treatment. Use of fluoxetine in anorexia nervosa before and after weight restoration.
These studies indicate that fluoxetine may help to treat depression and obsessive-compulsive disorder in children. Fluoxetine works by affecting a part of your brain that controls your mood. Fluoxetine is used to treat depression, obsessive-compulsive disorders, panic disorder, and bulimia (binge eating and purging). Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression or mood disturbances, eating disorders, or obsessive or compulsive symptoms. While you are taking fluoxetine you may need to be monitored for worsening symptoms of depression and suicidal thoughts at the start of therapy or when doses are changed.
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Fluoxetine should be offered to a child or young person with moderate to severe major depressive disorder only in combination with psychological therapy. Additionally, only limited information concerning the long-term safety of fluoxetine on growth, puberty, mental, emotional and behavioural development in this age group is available. In addition, do not start fluoxetine in a patient who is being treated with linezolid or intravenous methylene blue due to risk of serotonin syndrome. Treatment with fluoxetine and any concomitant serotonergic agents should be discontinued immediately if the above reactions occur, and supportive symptomatic treatment should be initiated.
Fluoxetine should be introduced with care in patients with a history of seizures. Rarely have patients discontinued treatment with fluoxetine because of anorexia or weight loss. Patients should be monitored for these symptoms when discontinuing treatment with fluoxetine. Fluoxetine delayed-released capsules are usually taken once a week.
Take fluoxetine at around the same time(s) every day. Continue to take fluoxetine even if you feel well. If you suddenly stop taking fluoxetine, you may experience withdrawal symptoms such as mood changes, irritability, agitation, dizziness, numbness or tingling in the hands or feet, anxiety, confusion, headache, tiredness, and difficulty falling asleep or staying asleep. Your doctor will probably tell you that you should not take fluoxetine. If you become pregnant while taking fluoxetine, call your doctor.
Samen met uw arts kunt u besluiten dat het voor u beter is om het gebruik van fluoxetine geleidelijk stop te zetten zolang u zwanger bent. Geef aan de apotheker door dat u overgevoelig bent voor fluoxetine. Ook als u gewend bent geraakt aan fluoxetine, kunt u door het gebruik van alcohol erg suf worden. Fluoxetine kan de werking van de bloedverdunner versterken.
Als u een van deze medicijnen samen met fluoxetine gebruikt, heeft u de eerste weken een verhoogde kans op een tekort aan natrium in het bloed. Fluoxetine kan de hoeveelheid metoprolol in het bloed verhogen. Fluoxetine versterkt de werking en bijwerkingen van deze medicijnen. Fluoxetine kan de hoeveelheid clozapine in het bloed verhogen en hierdoor de bijwerkingen van clozapine versterken. Fluoxetine kan het effect van tamoxifen verminderen.
Fluoxetine kan de bijwerkingen van perfenazine versterken, zoals sufheid en bewegingsstoornissen. Fluoxetine kan de hoeveelheid van deze medicijnen in het bloed verhogen. Fluoxetine kan de werking van atomoxetine versterken. Bij stoppen met fluoxetine kan de werking van atomoxetine afnemen. Deze mag u niet samen met fluoxetine gebruiken. Andersom duurt het twee weken voor u, na stoppen met deze medicijnen, met fluoxetine mag beginnen. Oorzaak: ik slik minder fluoxetine, en daardoor slaap ik weer.
Dus bijvoorbeeld hoeveel tabletten u per dag moet nemen. U mag deze tabletten niet kauwen of fijnmaken. I have noticed that in the prescription of the fluoxetine tablets it says that fluoxetine should be spread out and be taken one in the morning and one in the night. So, today we gived him two fluoxetine tablets together.
The study concluded it was unlikely that maternal fluoxetine use during the third trimester results in significant postnatal complications. In addition, the women who continued to take fluoxetine into the third trimester most likely had more severe psychiatric illnesses. Other reports from two lactating women taking fluoxetine have described milk fluoxetine and norfluoxetine concentrations to be about one-fifth to one-quarter of the serum concentrations. The cost of drug development is so high that few companies are willing to spend the money it takes to develop a canine-specific drug, or to run clinical trials testing human drugs for dogs or cats. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with fluoxetine.
The risk differences (drug versus placebo), however, were relatively stable within age strata and across indications. No reports involved the administration of methylene blue by other routes (such as oral tablets or local tissue injection) or at lower doses. Seizures have also been reported with both olanzapine and fluoxetine monotherapy. Results of a number of published epidemiological studies assessing the risk of fluoxetine exposure during the first trimester of pregnancy have demonstrated inconsistent results. Significant toxicity on muscle tissue, neurobehavior, reproductive organs, and bone development has been observed following exposure of juvenile rats to fluoxetine from weaning through maturity. The overall steady-state plasma concentrations of olanzapine and fluoxetine when given as the combination in the therapeutic dose ranges were comparable with those typically attained with each of the monotherapies.
R-norfluoxetine is significantly less potent than the parent drug in the inhibition of serotonin uptake. Plasma concentrations of fluoxetine were higher than those predicted by single-dose studies, because the metabolism of fluoxetine is not proportional to dose. However, olanzapine and fluoxetine individual pharmacokinetics do not differ significantly in patients with renal impairment. Olanzapine and fluoxetine can pass into your breastmilk and may harm your baby.