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Years of development and testing finally led to approval of fluoxetine for marketing. Three randomized, double-blind, placebo-controlled studies showed a decrease in the frequency and severity of migraine headaches with fluoxetine therapy. Because uptake inactivates serotonin by removing it from the synaptic cleft, uptake inhibition by fluoxetine enhances serotonergic function. Fluoxetine does not interact directly with postsynaptic serotonin receptors, muscarinic-cholinergic receptors, histaminergic receptors, or alpha-adrenergic receptors. The liver then metabolizes fluoxetine into norfluoxetine, a desmethyl metabolite, which is also a serotonin reuptake inhibitor.

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Fluoxetine versus other types of pharmacotherapy for depression. Possible involvement of cholinergic and opioid receptor mechanisms in fluoxetine mediated antinociception response in streptozotocin-induced diabetic mice. Plasma catecholamine levels after fluoxetine treatment in depressive patients. Fluoxetine for migraine prophylaxis: a double-blind trial. Fluoxetine prophylaxis of migraine. A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. The fetal safety of fluoxetine: a systematic review and meta-analysis. Fluoxetine attenuates alcohol intake and desire to drink.

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Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents. Double-blind trial of fluoxetine: chronic daily headache and migraine. Fluoxetine and premature ejaculation: a double-blind, crossover, placebo-controlled study. Double-blind placebo-controlled trial of fluoxetine in smoking cessation treatment including nicotine patch and cognitive-behavioral group therapy. The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. Fluoxetine and fluvoxamine for treatment of chronic pain. Fluoxetine for the treatment of childhood anxiety disorders.

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The effects of fluoxetine in the overdose patient. Benign course in a child with a massive fluoxetine overdose. Timing of onset of antidepressant response with fluoxetine treatment. Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort. Use of fluoxetine in anorexia nervosa before and after weight restoration. These studies indicate that fluoxetine may help to treat depression and obsessive-compulsive disorder in children.

Blackwell’s five-minute veterinary consult clinical companion. Fluoxetine works by affecting a part of your brain that controls your mood. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Visit your doctor or health care professional for regular checks on your progress. Fluoxetine is used to treat depression, obsessive-compulsive disorders, panic disorder, and bulimia (binge eating and purging).

Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression or mood disturbances, eating disorders, or obsessive or compulsive symptoms. While you are taking fluoxetine you may need to be monitored for worsening symptoms of depression and suicidal thoughts at the start of therapy or when doses are changed. This medication will cause you to become drowsy. I've ordered from both and they have good reputations online. Each entry lists the prescription drugs side effects.

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Their recommendations about medicines and dosages needs to be adopted on, that they can need to become acquainted with medicines and which is consequences. All examples are of a general nature only and should not be applied to your specific situation without first consulting your attorney or other advisers. It briefly outlines the most important things you need to know. Fluoxetine should be offered to a child or young person with moderate to severe major depressive disorder only in combination with psychological therapy. Additionally, only limited information concerning the long-term safety of fluoxetine on growth, puberty, mental, emotional and behavioural development in this age group is available.

The dose should be increased carefully to ensure that you receive the lowest effective dose. This is usual because an improvement in depressive symptoms may not occur until after the first few weeks. Abnormal liver function has been reported rarely, with very rare cases of hepatitis. In addition, do not start fluoxetine in a patient who is being treated with linezolid or intravenous methylene blue due to risk of serotonin syndrome. Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient’s presenting symptoms. Treatment with fluoxetine and any concomitant serotonergic agents should be discontinued immediately if the above reactions occur, and supportive symptomatic treatment should be initiated. Anaphylactoid reactions, including bronchospasm, angioedema, laryngospasm, and urticaria alone and in combination, have been reported.

Fluoxetine should be introduced with care in patients with a history of seizures. Rarely have patients discontinued treatment with fluoxetine because of anorexia or weight loss. Patients should be monitored for these symptoms when discontinuing treatment with fluoxetine. Be sure your doctor knows about all other medicines you use. Skip the missed dose if it is almost time for your next scheduled dose. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed. Call your doctor for medical advice about side effects.

The information contained herein is not intended to cover all possible uses directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. You should also talk about the risks and benefits of not treating your condition. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Fluoxetine delayed-released capsules are usually taken once a week. Take fluoxetine at around the same time(s) every day. Continue to take fluoxetine even if you feel well.

If you suddenly stop taking fluoxetine, you may experience withdrawal symptoms such as mood changes, irritability, agitation, dizziness, numbness or tingling in the hands or feet, anxiety, confusion, headache, tiredness, and difficulty falling asleep or staying asleep. Your doctor will probably tell you that you should not take fluoxetine. If you become pregnant while taking fluoxetine, call your doctor. Talk to your doctor about having an eye examination before you start taking this medication. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

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