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Anyone considering the use of fluoxetine or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Plant-based diets reduce the risk of heart disease. Years of development and testing finally led to approval of fluoxetine for marketing. Three randomized, double-blind, placebo-controlled studies showed a decrease in the frequency and severity of migraine headaches with fluoxetine therapy. Because uptake inactivates serotonin by removing it from the synaptic cleft, uptake inhibition by fluoxetine enhances serotonergic function. Fluoxetine does not interact directly with postsynaptic serotonin receptors, muscarinic-cholinergic receptors, histaminergic receptors, or alpha-adrenergic receptors.
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The liver then metabolizes fluoxetine into norfluoxetine, a desmethyl metabolite, which is also a serotonin reuptake inhibitor. Fluoxetine versus other types of pharmacotherapy for depression. Possible involvement of cholinergic and opioid receptor mechanisms in fluoxetine mediated antinociception response in streptozotocin-induced diabetic mice. Plasma catecholamine levels after fluoxetine treatment in depressive patients.
Fluoxetine for migraine prophylaxis: a double-blind trial. Fluoxetine prophylaxis of migraine. A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. The fetal safety of fluoxetine: a systematic review and meta-analysis. Fluoxetine attenuates alcohol intake and desire to drink. Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents. Double-blind trial of fluoxetine: chronic daily headache and migraine.
Fluoxetine and premature ejaculation: a double-blind, crossover, placebo-controlled study. Double-blind placebo-controlled trial of fluoxetine in smoking cessation treatment including nicotine patch and cognitive-behavioral group therapy. The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. Fluoxetine and fluvoxamine for treatment of chronic pain. Fluoxetine for the treatment of childhood anxiety disorders. The effects of fluoxetine in the overdose patient.
Benign course in a child with a massive fluoxetine overdose. Timing of onset of antidepressant response with fluoxetine treatment. Use of fluoxetine in anorexia nervosa before and after weight restoration. These studies indicate that fluoxetine may help to treat depression and obsessive-compulsive disorder in children. It is also used in veterinary practice to treat a wide range of behavioral issues. It helps to treat mood problems such as depression, obsessive compulsive disorder, and panic attacks. Fluoxetine works by affecting a part of your brain that controls your mood.
Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Visit your doctor or health care professional for regular checks on your progress. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. Fluoxetine is used to treat depression, obsessive-compulsive disorders, panic disorder, and bulimia (binge eating and purging). Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression or mood disturbances, eating disorders, or obsessive or compulsive symptoms.
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Oregon accepts certification from either one of these organizations. It briefly outlines the most important things you need to know. Fluoxetine should be offered to a child or young person with moderate to severe major depressive disorder only in combination with psychological therapy. Additionally, only limited information concerning the long-term safety of fluoxetine on growth, puberty, mental, emotional and behavioural development in this age group is available. Unless your doctor tells you to, do not keep these capsules for longer than you need. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behavior. In addition, do not start fluoxetine in a patient who is being treated with linezolid or intravenous methylene blue due to risk of serotonin syndrome.
Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient’s presenting symptoms. Treatment with fluoxetine and any concomitant serotonergic agents should be discontinued immediately if the above reactions occur, and supportive symptomatic treatment should be initiated. Although these reactions are rare, they may be serious, involving the lung, kidney, or liver. Anaphylactoid reactions, including bronchospasm, angioedema, laryngospasm, and urticaria alone and in combination, have been reported.